PrEP (pre-exposure prophylaxis) is a medication that prevents HIV infection. It comes in two forms:

Taken consistently, both forms are highly effective at preventing HIV.

Daily oral PrEP reduces HIV risk from sex by about 99%
Reduces risk from injection drug use by about 74%
Long-acting injectable PrEP is similarly effective when doses are received on schedule

Prescription from a healthcare provider
Many insurance plans cover PrEP; assistance programs are available for those without insurance
Lab tests (HIV, kidney function, STI screening) are required before starting and periodically during use

No- PrEP only prevents HIV. Condoms are still recommended for protection against other STIs.
Yes! PrEP is safe and effective for people of all genders who are at risk of HIV.
To learn more about women and PrEP, click here.
Most people experience mild side effects such as nausea, headache, or fatigue. These usually go away after a few weeks. Serious side effects are rare. Please reach out to your provider with any concerns regarding side effects.
Talk with a healthcare provider about your risk factors and which form of PrEP may fit your lifestyle.
For guidance on talking to providers about PrEP, click here.
Insurance coverage:
- Most insurance plans and Missouri Medicaid cover PrEP, including medication, lab tests, and office visits.
Uninsured individuals:
- Programs are available to help reduce or eliminate costs.
- Gilead Advancing Access® Program
  - Offers information and resources to help patients understand coverage and financial options for their prescribed Gilead medication.
- HIV.gov- Resources for Accessing PrEP
  - Provides information on national PrEP assistance programs and related services.
Visit the national PrEP Locator to find a provider near you.
Low Cost PrEP Providers in Columbia/Boone County:
- Columbia/Boone County Public Health and Human Services
- Spectrum Health Care
Virtual PrEP Services

Pre-Exposure Prophylaxis (PrEP)