Pre-Exposure Prophylaxis (PrEP)

What is PrEP?

PrEP (pre-exposure prophylaxis) is a medication that prevents HIV infection. It comes in two forms:

  • Daily oral pill– taken every day for maximum protection

  • Long-acting injectable PrEP– given by a healthcare provider every 2 months

Taken consistently, both forms are highly effective at preventing HIV.

Who should consider PrEP?

  • People with an HIV-positive partner

  • Individuals with multiple sexual partners and inconsistent condom use

  • People who inject drugs

  • Anyone seeking extra protection against HIV

How Effective is PrEP?

  • Daily oral PrEP reduces HIV risk from sex by about 99%

  • Reduces risk from injection drug use by about 74%

  • Long-acting injectable PrEP is similarly effective when doses are received on schedule

How Do I Get Started on PrEP?

  • Prescription from a healthcare provider

  • Many insurance plans cover PrEP; assistance programs are available for those without insurance

  • Lab tests (HIV, kidney function, STI screening) are required before starting and periodically during use

  • No- PrEP only prevents HIV. Condoms are still recommended for protection against other STIs.

  • Yes! PrEP is safe and effective for people of all genders who are at risk of HIV.

    Visit the CDC to learn more about women and PrEP.

  • Most people experience mild side effects such as nausea, headache, or fatigue. These usually go away after a few weeks. Serious side effects are rare. Please reach out to your provider with any concerns regarding side effects.

  • Talk with a healthcare provider about your risk factors and which form of PrEP may fit your lifestyle.

  • Insurance coverage:

    • Most insurance plans and Missouri Medicaid cover PrEP, including medication, lab tests, and office visits.

    Uninsured individuals:

  • Visit the national PrEP Locator to find a provider near you.

    Low Cost PrEP Providers in Columbia/Boone County:

    Virtual PrEP Services

PrEP FAQs

Infographic titled "PrEP 101" explaining that PrEP is medicine to prevent HIV. It notes it is highly effective when taken as prescribed, does not prevent other STDs, and may benefit HIV-negative people with recent risk, including unprotected sex.
PrEP 101 infographic section on accessing and paying for PrEP, including provider visits, follow-up care, symptoms, and cost assistance options like insurance, Medicaid, Ready, Set, PrEP, and assistance programs. CDC logo shown.